Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies

Protein lysine methylation plays important biological roles but its experimental characterization is limited by the lack of suitable mimetics of methylated and unmethylated lysine among the natural amino acids. Here, we summarize the consequent challenges and discuss alternative approaches for bioch...

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Autores principales: Weirich, Sara, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336004/
https://www.ncbi.nlm.nih.gov/pubmed/37433789
http://dx.doi.org/10.1038/s41467-023-39777-8
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author Weirich, Sara
Jeltsch, Albert
author_facet Weirich, Sara
Jeltsch, Albert
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description Protein lysine methylation plays important biological roles but its experimental characterization is limited by the lack of suitable mimetics of methylated and unmethylated lysine among the natural amino acids. Here, we summarize the consequent challenges and discuss alternative approaches for biochemical and cellular lysine methylation studies.
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spelling pubmed-103360042023-07-13 Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies Weirich, Sara Jeltsch, Albert Nat Commun Comment Protein lysine methylation plays important biological roles but its experimental characterization is limited by the lack of suitable mimetics of methylated and unmethylated lysine among the natural amino acids. Here, we summarize the consequent challenges and discuss alternative approaches for biochemical and cellular lysine methylation studies. Nature Publishing Group UK 2023-07-11 /pmc/articles/PMC10336004/ /pubmed/37433789 http://dx.doi.org/10.1038/s41467-023-39777-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Weirich, Sara
Jeltsch, Albert
Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies
title Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies
title_full Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies
title_fullStr Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies
title_full_unstemmed Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies
title_short Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies
title_sort limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336004/
https://www.ncbi.nlm.nih.gov/pubmed/37433789
http://dx.doi.org/10.1038/s41467-023-39777-8
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