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Predicting scale-dependent chromatin polymer properties from systematic coarse-graining

Simulating chromatin is crucial for predicting genome organization and dynamics. Although coarse-grained bead-spring polymer models are commonly used to describe chromatin, the relevant bead dimensions, elastic properties, and the nature of inter-bead potentials are unknown. Using nucleosome-resolut...

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Detalles Bibliográficos
Autores principales: Kadam, Sangram, Kumari, Kiran, Manivannan, Vinoth, Dutta, Shuvadip, Mitra, Mithun K., Padinhateeri, Ranjith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336007/
https://www.ncbi.nlm.nih.gov/pubmed/37433821
http://dx.doi.org/10.1038/s41467-023-39907-2