Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity

The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However, the molecular mechanisms by which 1-dSLs induce toxicity in retinal cells remain poorly understood. Here, we integrate bu...

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Detalles Bibliográficos
Autores principales: Rosarda, Jessica D., Giles, Sarah, Harkins-Perry, Sarah, Mills, Elizabeth A., Friedlander, Martin, Wiseman, R. Luke, Eade, Kevin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336013/
https://www.ncbi.nlm.nih.gov/pubmed/37433773
http://dx.doi.org/10.1038/s41467-023-39775-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336013/
https://www.ncbi.nlm.nih.gov/pubmed/37433773
http://dx.doi.org/10.1038/s41467-023-39775-w

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