Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability

How cells adapt their gene expression to nutritional changes remains poorly understood. Histone H3T11 is phosphorylated by pyruvate kinase to repress gene transcription. Here, we identify the protein phosphatase 1 (PP1), Glc7 as the enzyme that specifically dephosphorylates H3T11. We also characteri...

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Detalles Bibliográficos
Autores principales: Zhang, Xinyu, Yu, Qi, Wu, Yinsheng, Zhang, Yuan, He, Yi, Wang, Rongsha, Yu, Xilan, Li, Shanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336126/
https://www.ncbi.nlm.nih.gov/pubmed/37433812
http://dx.doi.org/10.1038/s41421-023-00551-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336126/
https://www.ncbi.nlm.nih.gov/pubmed/37433812
http://dx.doi.org/10.1038/s41421-023-00551-1

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