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Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily

The Ras superfamily of GTPases regulate critical cellular processes by shuttling between GTP-bound ON and GDP-bound OFF states. This switching mechanism is attributed to the conformational changes in two loops, SWI and SWII, upon GTP binding and hydrolysis. Since these conformational changes vary ac...

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Detalles Bibliográficos
Autores principales: Motiwala, Zenia, Sandholu, Anand S., Sengupta, Durba, Kulkarni, Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336170/
https://www.ncbi.nlm.nih.gov/pubmed/37448564
http://dx.doi.org/10.1016/j.isci.2023.107031