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Rethinking the network determinants of motor disability in Parkinson’s disease

For roughly the last 30 years, the notion that striatal dopamine (DA) depletion was the critical determinant of network pathophysiology underlying the motor symptoms of Parkinson’s disease (PD) has dominated the field. While the basal ganglia circuit model underpinning this hypothesis has been of gr...

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Detalles Bibliográficos
Autores principales: Surmeier, Dalton James, Zhai, Shenyu, Cui, Qiaoling, Simmons, DeNard V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336242/
https://www.ncbi.nlm.nih.gov/pubmed/37448451
http://dx.doi.org/10.3389/fnsyn.2023.1186484