A PAM of the α(1A)-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer’s disease mouse models without effects on blood pressure

α(1)-Adrenergic Receptors (ARs) regulate the sympathetic nervous system by the binding of norepinephrine (NE) and epinephrine (Epi) through different subtypes (α(1A), α(1B), α(1D)). α(1A)-AR activation is hypothesized to be memory forming and cognitive enhancing but drug development has been stagnan...

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Detalles Bibliográficos
Autores principales: Papay, Robert S., Stauffer, Shaun R., Perez, Dianne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336260/
https://www.ncbi.nlm.nih.gov/pubmed/37448695
http://dx.doi.org/10.1016/j.crphar.2023.100160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336260/
https://www.ncbi.nlm.nih.gov/pubmed/37448695
http://dx.doi.org/10.1016/j.crphar.2023.100160

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