Cargando…
A PAM of the α(1A)-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer’s disease mouse models without effects on blood pressure
α(1)-Adrenergic Receptors (ARs) regulate the sympathetic nervous system by the binding of norepinephrine (NE) and epinephrine (Epi) through different subtypes (α(1A), α(1B), α(1D)). α(1A)-AR activation is hypothesized to be memory forming and cognitive enhancing but drug development has been stagnan...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336260/ https://www.ncbi.nlm.nih.gov/pubmed/37448695 http://dx.doi.org/10.1016/j.crphar.2023.100160 |