Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis

OBJECTIVE: Cancer cells convert more glucose into lactate than healthy cells, what contributes to their growth advantage. Pyruvate kinase (PK) is a key rate limiting enzyme in this process, what makes it a promising potential therapeutic target. However, currently it is still unclear what consequenc...

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Detalles Bibliográficos
Autores principales: Nieborak, Anna, Lukauskas, Saulius, Capellades, Jordi, Heyn, Patricia, Santos, Gabriela Silva, Motzler, Karsten, Zeigerer, Anja, Bester, Romina, Protzer, Ulrike, Schelter, Florian, Wagner, Mirko, Carell, Thomas, Hruscha, Alexander, Schmid, Bettina, Yanes, Oscar, Schneider, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336528/
https://www.ncbi.nlm.nih.gov/pubmed/37290673
http://dx.doi.org/10.1016/j.molmet.2023.101748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336528/
https://www.ncbi.nlm.nih.gov/pubmed/37290673
http://dx.doi.org/10.1016/j.molmet.2023.101748

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