Cargando…

Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis

OBJECTIVE: Cancer cells convert more glucose into lactate than healthy cells, what contributes to their growth advantage. Pyruvate kinase (PK) is a key rate limiting enzyme in this process, what makes it a promising potential therapeutic target. However, currently it is still unclear what consequenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nieborak, Anna, Lukauskas, Saulius, Capellades, Jordi, Heyn, Patricia, Santos, Gabriela Silva, Motzler, Karsten, Zeigerer, Anja, Bester, Romina, Protzer, Ulrike, Schelter, Florian, Wagner, Mirko, Carell, Thomas, Hruscha, Alexander, Schmid, Bettina, Yanes, Oscar, Schneider, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336528/ https://www.ncbi.nlm.nih.gov/pubmed/37290673 http://dx.doi.org/10.1016/j.molmet.2023.101748

Ejemplares similares

Characterization of prickle isoform-specific pk (pk1) and pk (sple1) mutations in Drosophila melanogaster
por: Lilienthal, Anthony J, et al.
Publicado: (2022)

Complete Genome Sequence of the Pokeweed Mosaic Virus (PkMV)-New Jersey Isolate and Its Comparison to PkMV-MD and PkMV-PA
por: Di, Rong
Publicado: (2016)

Serine phosphorylation of the cotton cytosolic pyruvate kinase GhPK6 decreases its stability and activity
por: Zhang, Bing, et al.
Publicado: (2017)

Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer
por: Bandara, Indika A., et al.
Publicado: (2018)

Genome-Wide Analysis and Functional Characterization of Pyruvate Kinase (PK) Gene Family Modulating Rice Yield and Quality
por: Dong, Nannan, et al.
Publicado: (2022)

P717: AG946, A PYRUVATE KINASE (PK) ACTIVATOR IMPROVES PK PROPERTIES AND RED BLOOD CELL (RBC) METABOLISM UPON EX VIVO TREATMENT OF RBCS FROM PATIENTS WITH MYELODYSPLASTIC SYNDROMES
por: de Wilde, Jonathan, et al.
Publicado: (2023)

Benchmarking pK(a )prediction
por: Davies, Matthew N, et al.
Publicado: (2006)

In silico pK(a) prediction
por: Körner, Robert, et al.
Publicado: (2012)

Ceftobiprole: pharmacokinetics and PK/PD profile
por: Azanza Perea, José Ramón, et al.
Publicado: (2019)

In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis
por: Xiao, Xia, et al.
Publicado: (2015)

1321. Population Pharmacokinetic (PK) and Pharmacokinetic/Pharmacodynamic (PK/PD) Target Attainment Analyses for Dalbavancin in Pediatric Patients
por: Carrothers, Timothy J, et al.
Publicado: (2020)

Joint analysis of PK and immunogenicity outcomes using factorization model − a powerful approach for PK similarity study
por: Haliduola, Halimu N., et al.
Publicado: (2022)

Population PK and Semimechanistic PK/PD Modeling and Simulation of Relugolix Effects on Testosterone Suppression in Men with Prostate Cancer
por: Lee, Tien‐Yi, et al.
Publicado: (2022)

PK-sensitive PrP(Sc) Is Infectious and Shares Basic Structural Features with PK-resistant PrP(Sc)
por: Sajnani, Gustavo, et al.
Publicado: (2012)

Concerns about pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) studies in the new therapeutic area of COVID-19 infection
por: Venisse, Nicolas, et al.
Publicado: (2020)

Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
por: Sou, Tomás, et al.
Publicado: (2020)

In vivo Pharmacokinetic and Pharmacodynamic (PK/PD) Modeling and Establishment of the PK/PD Cutoff of Florfenicol Against Pasteurella multocida in Ducks
por: Xiao, Xia, et al.
Publicado: (2021)

PB1990: GLYCOLYTIC ACTIVITY AND EFFECT OF EX-VIVO TREATMENT WITH THE PYRUVATE KINASE (PK) ACTIVATOR AG-946 IN RED BLOOD CELLS FROM LOW-RISK MYELODYSPLASTIC SYNDROMES PATIENTS: A PROOF-OF-CONCEPT STUDY
por: Fattizzo, Bruno, et al.
Publicado: (2023)

Ionization Constants pK(a) of Cardiolipin
por: Olofsson, Gerd, et al.
Publicado: (2013)

DNA-PK as an Emerging Therapeutic Target in Cancer
por: Mohiuddin, Ismail S., et al.
Publicado: (2019)

Machine learning meets pK (a)
por: Baltruschat, Marcel, et al.
Publicado: (2020)

Prediction of Clinical Irrelevance of PK Differences in Atorvastatin Using PK/PD Models Derived From Literature-Based Meta-Analyses
por: Vargo, R, et al.
Publicado: (2014)

Simulation of the impact of rifampicin on darunavir/ritonavir PK and dose adjustment strategies in HIV-infected patients: a population PK approach
por: Dickinson, Laura, et al.
Publicado: (2014)

Epidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets
por: Zhou, Yu-Feng, et al.
Publicado: (2020)

1550. PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models
por: Ghahramani, Parviz, et al.
Publicado: (2019)

MF-SuP-pK(a): Multi-fidelity modeling with subgraph pooling mechanism for pK(a) prediction
por: Wu, Jialu, et al.
Publicado: (2023)

Plasmodium knowlesi (Pk) Malaria: A Review & Proposal of Therapeutically Rational Exchange (T-REX) of Pk-Resistant Red Blood Cells
por: Jajosky, Ryan Philip, et al.
Publicado: (2023)

Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China
por: Luo, Xinhua, et al.
Publicado: (2022)

PK/PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development
por: Oggianu, Laura, et al.
Publicado: (2023)

Identification of OsPK5 involved in rice glycolytic metabolism and GA/ABA balance for improving seed germination via genome-wide association study
por: Yang, Bin, et al.
Publicado: (2022)

Observation of the decay $\Xi^-_b \to pK^- K^-$
por: Mathad, Abhijit
Publicado: (2017)

Visualization of a DNA-PK/PARP1 complex
por: Spagnolo, Laura, et al.
Publicado: (2012)

Development of Methods for the Determination of pK(a) Values
por: Reijenga, Jetse, et al.
Publicado: (2013)

The functional exchangeability of pk- and k-turns in RNA structure
por: Daldrop, Peter, et al.
Publicado: (2013)

The PK/PD Interactions of Doxycycline against Mycoplasma gallisepticum
por: Zhang, Nan, et al.
Publicado: (2016)

1719. Pharmacokinetics (PK) of Oritavancin in Children: The ORKIDS Trial
por: Bradley, John, et al.
Publicado: (2018)

The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
por: Rodríguez-Gascón, Alicia, et al.
Publicado: (2021)

Protein pK(a) Prediction with Machine Learning
por: Cai, Zhitao, et al.
Publicado: (2021)

Prediction of protein pK(a) with representation learning
por: Gokcan, Hatice, et al.
Publicado: (2022)

Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats
por: Fernández-Varón, Emilio, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_b895c81g9gr7mh4pq64deidvlu