Bridging the diversity gap: Analytical and study design considerations for improving the accuracy of trans-ancestry genetic prediction

Genetic prediction of common complex disease risk is an essential component of precision medicine. Currently, genome-wide association studies (GWASs) are mostly composed of European-ancestry samples and resulting polygenic scores (PGSs) have been shown to poorly transfer to other ancestries partly d...

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Detalles Bibliográficos
Autores principales: Bocher, Ozvan, Gilly, Arthur, Park, Young-Chan, Zeggini, Eleftheria, Morris, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336686/
https://www.ncbi.nlm.nih.gov/pubmed/37448981
http://dx.doi.org/10.1016/j.xhgg.2023.100214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336686/
https://www.ncbi.nlm.nih.gov/pubmed/37448981
http://dx.doi.org/10.1016/j.xhgg.2023.100214

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