A Conserved Local Structural Motif Controls the Kinetics of PTP1B Catalysis

[Image: see text] Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin signaling pathways, making it a highly attractive target for the treatment of type II diabetes. For PTP1B to perform its enzymatic function, a loop referred to as the “WPD loop” must transitio...

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Detalles Bibliográficos
Autores principales: Yeh, Christine Y., Izaguirre, Jesus A., Greisman, Jack B., Willmore, Lindsay, Maragakis, Paul, Shaw, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336961/
https://www.ncbi.nlm.nih.gov/pubmed/37378552
http://dx.doi.org/10.1021/acs.jcim.3c00286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336961/
https://www.ncbi.nlm.nih.gov/pubmed/37378552
http://dx.doi.org/10.1021/acs.jcim.3c00286

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