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A Conserved Local Structural Motif Controls the Kinetics of PTP1B Catalysis
[Image: see text] Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin signaling pathways, making it a highly attractive target for the treatment of type II diabetes. For PTP1B to perform its enzymatic function, a loop referred to as the “WPD loop” must transitio...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336961/ https://www.ncbi.nlm.nih.gov/pubmed/37378552 http://dx.doi.org/10.1021/acs.jcim.3c00286 |