SEESAW: detecting isoform-level allelic imbalance accounting for inferential uncertainty

Detecting allelic imbalance at the isoform level requires accounting for inferential uncertainty, caused by multi-mapping of RNA-seq reads. Our proposed method, SEESAW, uses Salmon and Swish to offer analysis at various levels of resolution, including gene, isoform, and aggregating isoforms to group...

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Detalles Bibliográficos
Autores principales: Wu, Euphy Y., Singh, Noor P., Choi, Kwangbom, Zakeri, Mohsen, Vincent, Matthew, Churchill, Gary A., Ackert-Bicknell, Cheryl L., Patro, Rob, Love, Michael I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337143/
https://www.ncbi.nlm.nih.gov/pubmed/37438847
http://dx.doi.org/10.1186/s13059-023-03003-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337143/
https://www.ncbi.nlm.nih.gov/pubmed/37438847
http://dx.doi.org/10.1186/s13059-023-03003-x

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