Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults

BACKGROUND: Gene expression is dysregulated in Alzheimer’s disease (AD) patients, both in peripheral blood and post mortem brain. We investigated peripheral whole-blood gene (co)expression to determine molecular changes prior to symptom onset. METHODS: RNA was extracted and sequenced for 65 cognitiv...

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Detalles Bibliográficos
Autores principales: Luckett, Emma S., Zielonka, Magdalena, Kordjani, Amine, Schaeverbeke, Jolien, Adamczuk, Katarzyna, De Meyer, Steffi, Van Laere, Koen, Dupont, Patrick, Cleynen, Isabelle, Vandenberghe, Rik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337180/
https://www.ncbi.nlm.nih.gov/pubmed/37438770
http://dx.doi.org/10.1186/s13195-023-01242-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337180/
https://www.ncbi.nlm.nih.gov/pubmed/37438770
http://dx.doi.org/10.1186/s13195-023-01242-5

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