Cargando…

Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults

BACKGROUND: Gene expression is dysregulated in Alzheimer’s disease (AD) patients, both in peripheral blood and post mortem brain. We investigated peripheral whole-blood gene (co)expression to determine molecular changes prior to symptom onset. METHODS: RNA was extracted and sequenced for 65 cognitiv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luckett, Emma S., Zielonka, Magdalena, Kordjani, Amine, Schaeverbeke, Jolien, Adamczuk, Katarzyna, De Meyer, Steffi, Van Laere, Koen, Dupont, Patrick, Cleynen, Isabelle, Vandenberghe, Rik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337180/ https://www.ncbi.nlm.nih.gov/pubmed/37438770 http://dx.doi.org/10.1186/s13195-023-01242-5

Ejemplares similares

Longitudinal changes in (18)F-Flutemetamol amyloid load in cognitively intact APOE4 carriers versus noncarriers: Methodological considerations
por: Luckett, Emma S., et al.
Publicado: (2023)

Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults
por: Luckett, Emma S., et al.
Publicado: (2022)

Changes in the language system as amyloid-β accumulates
por: Reinartz, Mariska, et al.
Publicado: (2021)

Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults
por: Schaeverbeke, Jolien M., et al.
Publicado: (2021)

Lack of association between bridging integrator 1 (BIN1) rs744373 polymorphism and tau‐PET load in cognitively intact older adults
por: Schaeverbeke, Jolien, et al.
Publicado: (2022)

Classification of (18)F-Flutemetamol scans in cognitively normal older adults using machine learning trained with neuropathology as ground truth
por: Reinartz, Mariska, et al.
Publicado: (2022)

Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease()
por: Vandenberghe, Rik, et al.
Publicado: (2013)

Phospho‐specific plasma p‐tau181 assay detects clinical as well as asymptomatic Alzheimer's disease
por: De Meyer, Steffi, et al.
Publicado: (2022)

Diagnostic value of cerebrospinal fluid Aβ ratios in preclinical Alzheimer’s disease
por: Adamczuk, Katarzyna, et al.
Publicado: (2015)

Prognostic value of amyloid/tau/neurodegeneration (ATN) classification based on diagnostic cerebrospinal fluid samples for Alzheimer’s disease
por: Delmotte, Koen, et al.
Publicado: (2021)

Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers()
por: Adamczuk, Katarzyna, et al.
Publicado: (2013)

Amnestic MCI Patients’ Perspectives toward Disclosure of Amyloid PET Results in a Research Context
por: Vanderschaeghe, Gwendolien, et al.
Publicado: (2017)

Serum neurofilament heavy chains as early marker of motor neuron degeneration
por: De Schaepdryver, Maxim, et al.
Publicado: (2019)

Amnestic MCI patients’ experiences after disclosure of their amyloid PET result in a research context
por: Vanderschaeghe, Gwendolien, et al.
Publicado: (2017)

From information to follow-up: Ethical recommendations to facilitate the disclosure of amyloid PET scan results in a research setting
por: Vanderschaeghe, Gwendolien, et al.
Publicado: (2018)

Cholinergic depletion and basal forebrain volume in primary progressive aphasia
por: Schaeverbeke, Jolien, et al.
Publicado: (2016)

Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants
por: Schaeverbeke, Jolien, et al.
Publicado: (2018)

Reproducibility of graph measures at the subject level using resting‐state fMRI
por: Ran, Qian, et al.
Publicado: (2020)

Posterior Intraparietal Sulcus Mediates Detection of Salient Stimuli Outside the Endogenous Focus of Attention
por: Jamoulle, Tarik, et al.
Publicado: (2021)

Binding of [(18)F]AV1451 in post mortem brain slices of semantic variant primary progressive aphasia patients
por: Schaeverbeke, Jolien, et al.
Publicado: (2019)

Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis
por: De Meyer, Steffi, et al.
Publicado: (2020)

Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia
por: Schaeverbeke, Jolien, et al.
Publicado: (2018)

Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression
por: Takamiya, Akihiro, et al.
Publicado: (2021)

Reproducibility and Robustness of Graph Measures of the Associative-Semantic Network
por: Wang, Yu, et al.
Publicado: (2014)

Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT
por: Declercq, Lieven D., et al.
Publicado: (2016)

Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition
por: Wesenhagen, Kirsten E.J., et al.
Publicado: (2022)

CSF Proteomic Alzheimer’s Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals
por: Tijms, Betty Marije, et al.
Publicado: (2021)

Core auditory processing deficits in primary progressive aphasia
por: Grube, Manon, et al.
Publicado: (2016)

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy
por: Camacho, Jessica, et al.
Publicado: (2019)

APOE-amyloid interaction: Therapeutic targets
por: Wisniewski, Thomas, et al.
Publicado: (2020)

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia
por: Salvadó, Gemma, et al.
Publicado: (2021)

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation†
por: Zhou, Lujia, et al.
Publicado: (2011)

A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease
por: Nordberg, Agneta, et al.
Publicado: (2012)

Left Frontal White Matter Links to Rhythm Processing Relevant to Speech Production in Apraxia of Speech
por: Bruffaerts, Rose, et al.
Publicado: (2022)

Comparison of intact protein and digested peptide techniques for high throughput proteotyping of ApoE
por: Maus, Anthony, et al.
Publicado: (2022)

Moral processing deficit in behavioral variant frontotemporal dementia is associated with facial emotion recognition and brain changes in default mode and salience network areas
por: Van den Stock, Jan, et al.
Publicado: (2017)

ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype
por: Caesar, Ina, et al.
Publicado: (2023)

ApoE facilitates the microglial response to amyloid plaque pathology
por: Ulrich, Jason D., et al.
Publicado: (2018)

Simplified Edinburgh and modified Boston criteria in relation to amyloid PET for lobar intracerebral hemorrhage
por: Michiels, Laura, et al.
Publicado: (2022)

Quantitative Analyses Help in Choosing Between Simultaneous vs. Separate EEG and fMRI
por: Schrooten, Maarten, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qdefpjo1ek7d2o81tk4ogncf3m