A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9

BACKGROUND: Adenine base editors (ABEs) are promising therapeutic gene editing tools that can efficiently convert targeted A•T to G•C base pairs in the genome. However, the large size of commonly used ABEs based on SpCas9 hinders its delivery in vivo using certain vectors such as adeno-associated vi...

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Detalles Bibliográficos
Autores principales: Qian, Yuqiang, Wang, Di, Niu, Wenchao, Zhao, Ding, Li, Jinze, Liu, Zhiquan, Gao, Xun, Han, Yang, Lai, Liangxue, Li, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337206/
https://www.ncbi.nlm.nih.gov/pubmed/37434184
http://dx.doi.org/10.1186/s12915-023-01644-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337206/
https://www.ncbi.nlm.nih.gov/pubmed/37434184
http://dx.doi.org/10.1186/s12915-023-01644-9

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