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Comparing Top-Down Proteoform Identification: Deconvolution, PrSM Overlap, and PTM Detection
[Image: see text] Generating top-down tandem mass spectra (MS/MS) from complex mixtures of proteoforms benefits from improvements in fractionation, separation, fragmentation, and mass analysis. The algorithms to match MS/MS to sequences have undergone a parallel evolution, with both spectral alignme...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337255/ https://www.ncbi.nlm.nih.gov/pubmed/37235544 http://dx.doi.org/10.1021/acs.jproteome.2c00673 |