Comparing Top-Down Proteoform Identification: Deconvolution, PrSM Overlap, and PTM Detection

[Image: see text] Generating top-down tandem mass spectra (MS/MS) from complex mixtures of proteoforms benefits from improvements in fractionation, separation, fragmentation, and mass analysis. The algorithms to match MS/MS to sequences have undergone a parallel evolution, with both spectral alignme...

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Detalles Bibliográficos
Autores principales: Tabb, David L., Jeong, Kyowon, Druart, Karen, Gant, Megan S., Brown, Kyle A., Nicora, Carrie, Zhou, Mowei, Couvillion, Sneha, Nakayasu, Ernesto, Williams, Janet E., Peterson, Haley K., McGuire, Michelle K., McGuire, Mark A., Metz, Thomas O., Chamot-Rooke, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337255/
https://www.ncbi.nlm.nih.gov/pubmed/37235544
http://dx.doi.org/10.1021/acs.jproteome.2c00673

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