The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells

The mechanoelectrical transduction (MET) channel of cochlear hair cells is gated by the tip link, but the mechanisms that establish the exquisite force sensitivity of this MET channel are not known. Here, we show that the tetraspan lipoma HMGIC fusion partner-like 5 (LHFPL5) directly couples the tip...

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Detalles Bibliográficos
Autores principales: Qiu, Xufeng, Liang, Xiaoping, Llongueras, Jose P., Cunningham, Christopher, Müller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337519/
https://www.ncbi.nlm.nih.gov/pubmed/36917610
http://dx.doi.org/10.1016/j.celrep.2023.112245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337519/
https://www.ncbi.nlm.nih.gov/pubmed/36917610
http://dx.doi.org/10.1016/j.celrep.2023.112245

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