Cargando…

SHH PATHWAY ACTIVATION DRIVES MALIGNANT TRANSFORMATION IN A SUBSET OF MPNSTS AND IS A POTENTIAL THERAPEUTIC TARGET

BTFC travel award recipient Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann-cell derived sarcomas and the leading cause of mortality in Neurofibromatosis Type 1. The molecular pathways driving malignant transformation is not well understood. In this study, we leverage...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suppiah, Suganth, Mansouri, Sheila, Liu, Jeff, Patel, Vikas, Bunda, Severa, Zadeh, Gelareh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Oral Abstract Presentations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337529/ http://dx.doi.org/10.1093/noajnl/vdad071.005

Ejemplares similares

MULTIPLATFORM MOLECULAR ANALYSIS OF VESTIBULAR SCHWANNOMA REVEALS TWO ROBUST SUBGROUPS WITH DISTINCT MICROENVIRONMENT
por: Landry, Alexander P, et al.
Publicado: (2023)

Special issue: a contemporary landscape of the clinical and biological research in neurofibromatosis type 1
por: Suppiah, Suganth, et al.
Publicado: (2020)

Programmed death ligand-1 (PD-L1) expression in meningioma; prognostic significance and its association with hypoxia and NFKB2 expression
por: Karimi, Shirin, et al.
Publicado: (2020)

Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors
por: Bunda, Severa, et al.
Publicado: (2021)

Molecular and Clinical Insights into the Invasive Capacity of Glioblastoma Cells
por: Velásquez, Carlos, et al.
Publicado: (2019)

Clinical significance of checkpoint regulator “Programmed death ligand-1 (PD-L1)” expression in meningioma: review of the current status
por: Karimi, Shirin, et al.
Publicado: (2021)

Multiplatform molecular analysis of vestibular schwannoma reveals two robust subgroups with distinct microenvironment
por: Landry, Alexander P., et al.
Publicado: (2023)

Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities
por: Suppiah, Suganth, et al.
Publicado: (2023)

SHH PATHWAY ACTIVATION IN DEDIFFERENTIATION DURING TUMOR PROGRESSION IN MPNST
por: Yakubov, R Y, et al.
Publicado: (2023)

METABOLOGENOMIC CHARACTERIZATION UNCOVERS HETEROGENEITY AMONG IDH MUTANT GLIOMAS
por: Ajisebutu, Andrew, et al.
Publicado: (2023)

TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy
por: Wei, Qingxia, et al.
Publicado: (2021)

The central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient care
por: Karimi, Shirin, et al.
Publicado: (2019)

Quality of life in patients with neurofibromatosis type 1 and 2 in Canada
por: Hamoy-Jimenez, Geohana, et al.
Publicado: (2020)

Malignant transformation of plexiform neurofibroma to MPNST while on MEK inhibitor
por: Fasih, Samir, et al.
Publicado: (2021)

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
por: Agnihotri, Sameer, et al.
Publicado: (2017)

SONIC HEDGEHOG (SHH) PROMOTES BLOOD-BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE MIDLINE GLIOMA OF THE PONS
por: Line, Stacey, et al.
Publicado: (2023)

Frequent EGFR Positivity and Overexpression in High-Grade Areas of Human MPNSTs
por: Tabone-Eglinger, Séverine, et al.
Publicado: (2008)

Extended Endoscopic Approach for Resection of Craniopharyngiomas
por: Almeida, João Paulo, et al.
Publicado: (2018)

Dendritic cell vaccines for high-grade gliomas
por: Eagles, Matthew E, et al.
Publicado: (2018)

Malignant hyperthermia testing in probands with NO adverse anesthetic reaction
por: Sterling, Carly, et al.
Publicado: (2014)

Combination therapies for MPNSTs targeting RABL6A-RB1 signaling
por: Kohlmeyer, Jordan L., et al.
Publicado: (2021)

Distinct DC subsets are not equally susceptible to HTLV-1 infection
por: Alais, Sandrine, et al.
Publicado: (2014)

Accuracy of the diagnosis of malignant hyperthermia in hospital discharge records
por: Pinyavat, Teeda, et al.
Publicado: (2014)

HIV infection destabilizes a targeted subset of the gamma/delta T cell repertoire
por: Hebbeler, Andrew M, et al.
Publicado: (2006)

OA10 Pregnancy-associated osteoporosis - a rare subset of bone disease
por: Xia, Zhongyang, et al.
Publicado: (2023)

Preservation of a subset of SIV-specific central memory CD4+ T cells correlates with control of viremia in SIVmac251 infected macaques
por: Felber, Barbara K, et al.
Publicado: (2006)

Prediction of driving behavior based on emotional intelligence & driving risk perception
por: Afsari, Masoumeh, et al.
Publicado: (2019)

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
por: Bunda, Severa, et al.
Publicado: (2015)

COMPREHENSIVE MULTIPLATFORM ANALYSIS OF CDKN2A ALTERATIONS IN MENINGIOMAS
por: Wang, Justin Z, et al.
Publicado: (2023)

Influence of site and smoking on malignant transformation in the oral cavity: Is the microbiome the missing link?
por: Galvin, Sheila, et al.
Publicado: (2023)

The Evolving Role of Radiosurgery in the Management of Radiation-Induced Meningiomas: A Review of Current Advances and Future Directions
por: Mansouri, Alireza, et al.
Publicado: (2014)

Influence of CD38/PD1 co-expression on T cell subsets in HIV-TB co-infection
por: Sunder, Sharada Ramaseri, et al.
Publicado: (2012)

Single-cell analysis techniques reveal a striking heterogeneity of human CD4(+) T cell subsets
por: Coffre, M, et al.
Publicado: (2010)

Vaccination with MVA/HIV induces differential recruitment of monocyte subsets into the circulation and monocyte-specific transcriptional programs
por: Andersen-Nissen, E, et al.
Publicado: (2012)

O078 A Comparison of Subjective Sleepiness and Subjective driving Performance between People Vulnerable Versus Resistant to Driving Impairment following Extended Wakefulness.
por: Nguyen, K, et al.
Publicado: (2023)

Factors of influence upon overall survival in the treatment of intracranial MPNSTs. Review of the literature and report of a case
por: Gousias, Konstantinos, et al.
Publicado: (2010)

Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs
por: Scherer, Amanda, et al.
Publicado: (2020)

Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities
por: Grit, Jamie L., et al.
Publicado: (2020)

P406 Rise in HIV negative Cryptococcal infection in liver disease patient: epidemiology, risk factor, antifungal susceptibility profile from tertiary care hepatobiliary center
por: Patel, Dhruvi, et al.
Publicado: (2022)

P438 Epidemiology, risk factor analysis and management of invasive Candida auris infections in tertiary care hepatobiliary center in India
por: Patel, Niharika, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dq5ngpioq9gsfj929jibtro0bl