Design, synthesis, in silico, and in vitro evaluation of benzylbenzimidazolone derivatives as potential drugs on α-glucosidase and glucokinase as pharmacological targets

Benzimidazolones have shown biological activities, including antihyperglycemic and hypoglycemic, by inhibiting or activating of α-glu and GK. The aim of this study is the rational design of compounds using in silico assays to delimitate the selection of structures to synthesize and the in vitro eval...

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Detalles Bibliográficos
Autores principales: Santos-Ballardo, Cress Lumadhar, Montes-Ávila, Julio, Rendon-Maldonado, José Guadalupe, Ramos-Payan, Rosalio, Montaño, Sarita, Sarmiento-Sánchez, Juan I., Acosta-Cota, Selene de Jesús, Ochoa-Terán, Adrián, Bastidas-Bastidas, Pedro de Jesús, Osuna-Martínez, Ulises
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337652/
https://www.ncbi.nlm.nih.gov/pubmed/37449031
http://dx.doi.org/10.1039/d3ra02916f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337652/
https://www.ncbi.nlm.nih.gov/pubmed/37449031
http://dx.doi.org/10.1039/d3ra02916f

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