Cargando…
Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams
A palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes via C(sp(3))–H activation has been developed for the synthesis of cyclopropane-fused γ-lactams. The presented strategy proceeds in a selective and 100% atom-economical manner. A range of cyclopropane-fused γ-lactams w...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337766/ https://www.ncbi.nlm.nih.gov/pubmed/37449077 http://dx.doi.org/10.1039/d3sc02168h |
| Sumario: | A palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes via C(sp(3))–H activation has been developed for the synthesis of cyclopropane-fused γ-lactams. The presented strategy proceeds in a selective and 100% atom-economical manner. A range of cyclopropane-fused γ-lactams were prepared from readily available substrates in good yields and enantioselectivities with a chiral phosphoramidite ligand. |
|---|