Cargando…
Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams
A palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes via C(sp(3))–H activation has been developed for the synthesis of cyclopropane-fused γ-lactams. The presented strategy proceeds in a selective and 100% atom-economical manner. A range of cyclopropane-fused γ-lactams w...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337766/ https://www.ncbi.nlm.nih.gov/pubmed/37449077 http://dx.doi.org/10.1039/d3sc02168h |
| _version_ | 1785071486310023168 |
|---|---|
| author | Lin, Han-Ze Qi, Zhuang Wu, Qi-Min Jiang, Yong-Yu Peng, Jin-Bao |
| author_facet | Lin, Han-Ze Qi, Zhuang Wu, Qi-Min Jiang, Yong-Yu Peng, Jin-Bao |
| author_sort | Lin, Han-Ze |
| collection | PubMed |
| description | A palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes via C(sp(3))–H activation has been developed for the synthesis of cyclopropane-fused γ-lactams. The presented strategy proceeds in a selective and 100% atom-economical manner. A range of cyclopropane-fused γ-lactams were prepared from readily available substrates in good yields and enantioselectivities with a chiral phosphoramidite ligand. |
| format | Online Article Text |
| id | pubmed-10337766 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103377662023-07-13 Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams Lin, Han-Ze Qi, Zhuang Wu, Qi-Min Jiang, Yong-Yu Peng, Jin-Bao Chem Sci Chemistry A palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes via C(sp(3))–H activation has been developed for the synthesis of cyclopropane-fused γ-lactams. The presented strategy proceeds in a selective and 100% atom-economical manner. A range of cyclopropane-fused γ-lactams were prepared from readily available substrates in good yields and enantioselectivities with a chiral phosphoramidite ligand. The Royal Society of Chemistry 2023-06-16 /pmc/articles/PMC10337766/ /pubmed/37449077 http://dx.doi.org/10.1039/d3sc02168h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Lin, Han-Ze Qi, Zhuang Wu, Qi-Min Jiang, Yong-Yu Peng, Jin-Bao Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams |
| title | Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams |
| title_full | Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams |
| title_fullStr | Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams |
| title_full_unstemmed | Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams |
| title_short | Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams |
| title_sort | palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337766/ https://www.ncbi.nlm.nih.gov/pubmed/37449077 http://dx.doi.org/10.1039/d3sc02168h |
| work_keys_str_mv | AT linhanze palladiumcatalyzedintramolecularasymmetrichydrocyclopropanylationofalkynessynthesisofcyclopropanefusedglactams AT qizhuang palladiumcatalyzedintramolecularasymmetrichydrocyclopropanylationofalkynessynthesisofcyclopropanefusedglactams AT wuqimin palladiumcatalyzedintramolecularasymmetrichydrocyclopropanylationofalkynessynthesisofcyclopropanefusedglactams AT jiangyongyu palladiumcatalyzedintramolecularasymmetrichydrocyclopropanylationofalkynessynthesisofcyclopropanefusedglactams AT pengjinbao palladiumcatalyzedintramolecularasymmetrichydrocyclopropanylationofalkynessynthesisofcyclopropanefusedglactams |