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An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
Generation of functionally mature organs requires exquisite control of transcriptional programs governing cell state transitions during development. Despite advances in understanding the behavior of adult intestinal stem cells and their progeny, the transcriptional regulators that control the emerge...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337909/ https://www.ncbi.nlm.nih.gov/pubmed/37436979 http://dx.doi.org/10.1126/sciadv.adg4055 |