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An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate

Generation of functionally mature organs requires exquisite control of transcriptional programs governing cell state transitions during development. Despite advances in understanding the behavior of adult intestinal stem cells and their progeny, the transcriptional regulators that control the emerge...

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Detalles Bibliográficos
Autores principales: Hansen, Stine L., Larsen, Hjalte L., Pikkupeura, Laura M., Maciag, Grzegorz, Guiu, Jordi, Müller, Iris, Clement, Ditte L., Mueller, Christina, Johansen, Jens Vilstrup, Helin, Kristian, Lerdrup, Mads, Jensen, Kim B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337909/
https://www.ncbi.nlm.nih.gov/pubmed/37436979
http://dx.doi.org/10.1126/sciadv.adg4055