Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection

Most of our understanding of folate metabolism in the parasite Leishmania is derived from studies of resistance to the antifolate methotrexate (MTX). A chemical mutagenesis screen of L. major Friedlin and selection for resistance to MTX led to twenty mutants with a 2- to 400-fold decrease in MTX sus...

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Detalles Bibliográficos
Autores principales: Bigot, Sophia, Leprohon, Philippe, Ouellette, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337921/
https://www.ncbi.nlm.nih.gov/pubmed/37384801
http://dx.doi.org/10.1371/journal.pntd.0011458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337921/
https://www.ncbi.nlm.nih.gov/pubmed/37384801
http://dx.doi.org/10.1371/journal.pntd.0011458

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