PINK1: From Parkinson’s disease to mitophagy and back again

The genetics of Parkinson’s disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade.

Detalles Bibliográficos
Autores principales: O’Callaghan, Benjamin, Hardy, John, Plun-Favreau, Helene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337960/
https://www.ncbi.nlm.nih.gov/pubmed/37384773
http://dx.doi.org/10.1371/journal.pbio.3002196
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author O’Callaghan, Benjamin
Hardy, John
Plun-Favreau, Helene
author_facet O’Callaghan, Benjamin
Hardy, John
Plun-Favreau, Helene
author_sort O’Callaghan, Benjamin
collection PubMed
description The genetics of Parkinson’s disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade.
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spelling pubmed-103379602023-07-13 PINK1: From Parkinson’s disease to mitophagy and back again O’Callaghan, Benjamin Hardy, John Plun-Favreau, Helene PLoS Biol Perspective The genetics of Parkinson’s disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade. Public Library of Science 2023-06-29 /pmc/articles/PMC10337960/ /pubmed/37384773 http://dx.doi.org/10.1371/journal.pbio.3002196 Text en © 2023 O’Callaghan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Perspective
O’Callaghan, Benjamin
Hardy, John
Plun-Favreau, Helene
PINK1: From Parkinson’s disease to mitophagy and back again
title PINK1: From Parkinson’s disease to mitophagy and back again
title_full PINK1: From Parkinson’s disease to mitophagy and back again
title_fullStr PINK1: From Parkinson’s disease to mitophagy and back again
title_full_unstemmed PINK1: From Parkinson’s disease to mitophagy and back again
title_short PINK1: From Parkinson’s disease to mitophagy and back again
title_sort pink1: from parkinson’s disease to mitophagy and back again
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337960/
https://www.ncbi.nlm.nih.gov/pubmed/37384773
http://dx.doi.org/10.1371/journal.pbio.3002196
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AT plunfavreauhelene pink1fromparkinsonsdiseasetomitophagyandbackagain

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