Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

Cys-loop receptors or pentameric ligand-gated ion channels are mediators of electrochemical signaling throughout the animal kingdom. Because of their critical function in neurotransmission and high potential as drug targets, Cys-loop receptors from humans and closely related organisms have been thor...

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Detalles Bibliográficos
Autores principales: De Gieter, Steven, Gallagher, Casey I, Wijckmans, Eveline, Pasini, Diletta, Ulens, Chris, Efremov, Rouslan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
https://www.ncbi.nlm.nih.gov/pubmed/37395731
http://dx.doi.org/10.7554/eLife.86029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338036/
https://www.ncbi.nlm.nih.gov/pubmed/37395731
http://dx.doi.org/10.7554/eLife.86029

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