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Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor
Cys-loop receptors or pentameric ligand-gated ion channels are mediators of electrochemical signaling throughout the animal kingdom. Because of their critical function in neurotransmission and high potential as drug targets, Cys-loop receptors from humans and closely related organisms have been thor...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338036/ https://www.ncbi.nlm.nih.gov/pubmed/37395731 http://dx.doi.org/10.7554/eLife.86029 |