CovET: A covariation-evolutionary trace method that identifies protein structure–function modules

Measuring the relative effect that any two sequence positions have on each other may improve protein design or help better interpret coding variants. Current approaches use statistics and machine learning but rarely consider phylogenetic divergences which, as shown by Evolutionary Trace studies, pro...

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Detalles Bibliográficos
Autores principales: Konecki, Daniel M., Hamrick, Spencer, Wang, Chen, Agosto, Melina A., Wensel, Theodore G., Lichtarge, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338321/
https://www.ncbi.nlm.nih.gov/pubmed/37290531
http://dx.doi.org/10.1016/j.jbc.2023.104896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338321/
https://www.ncbi.nlm.nih.gov/pubmed/37290531
http://dx.doi.org/10.1016/j.jbc.2023.104896

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