Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the restriction point of the cell cycle(1,2), when mitogen signalling engages a positive feedback loop between cyclin A2/cyclin-dependent kinase 2 (CDK2) and the retinoblastoma protein(3–5). Contrary to this textbo...

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Detalles Bibliográficos
Autores principales: Cornwell, James A., Crncec, Adrijana, Afifi, Marwa M., Tang, Kristina, Amin, Ruhul, Cappell, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338338/
https://www.ncbi.nlm.nih.gov/pubmed/37407814
http://dx.doi.org/10.1038/s41586-023-06274-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338338/
https://www.ncbi.nlm.nih.gov/pubmed/37407814
http://dx.doi.org/10.1038/s41586-023-06274-3

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