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Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal
In mammalian cells, the decision to proliferate is thought to be irreversibly made at the restriction point of the cell cycle(1,2), when mitogen signalling engages a positive feedback loop between cyclin A2/cyclin-dependent kinase 2 (CDK2) and the retinoblastoma protein(3–5). Contrary to this textbo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338338/ https://www.ncbi.nlm.nih.gov/pubmed/37407814 http://dx.doi.org/10.1038/s41586-023-06274-3 |