A Population Pharmacokinetic Model of Pentobarbital for Children with Status Epilepticus and Severe Traumatic Brain Injury

BACKGROUND: Pentobarbital pharmacokinetics (PK) remain elusive and the therapeutic windows narrow. Administration is frequent in critically ill children with refractory status epilepticus (SE) and severe traumatic brain injury (sTBI). OBJECTIVES: To investigate pentobarbital PK in SE and sTBI patien...

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Detalles Bibliográficos
Autores principales: Ketharanathan, Naomi, Lili, Anastasia, de Vries, Julia M. Penning, Wildschut, Enno D., de Hoog, Matthijs, Koch, Birgit C. P., de Winter, Brenda C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338388/
https://www.ncbi.nlm.nih.gov/pubmed/37247187
http://dx.doi.org/10.1007/s40262-023-01249-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338388/
https://www.ncbi.nlm.nih.gov/pubmed/37247187
http://dx.doi.org/10.1007/s40262-023-01249-z

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