Unambiguous Identification of Glucose-Induced Glycation in mAbs and other Proteins by NMR Spectroscopy

OBJECTIVE: Glycation is a non-enzymatic and spontaneous post-translational modification (PTM) generated by the reaction between reducing sugars and primary amine groups within proteins. Because glycation can alter the properties of proteins, it is a critical quality attribute of therapeutic monoclon...

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Detalles Bibliográficos
Autores principales: Moises, Jennifer E., Regl, Christof, Hinterholzer, Arthur, Huber, Christian G., Schubert, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338404/
https://www.ncbi.nlm.nih.gov/pubmed/36510116
http://dx.doi.org/10.1007/s11095-022-03454-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338404/
https://www.ncbi.nlm.nih.gov/pubmed/36510116
http://dx.doi.org/10.1007/s11095-022-03454-0

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