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Metformin improves fibroblast metabolism and ameliorates arthrofibrosis in rats

BACKGROUND: Emerging studies have suggested an essential role of fibroblast metabolic reprogramming in the pathogenesis of arthrofibrosis. The metabolic modulator metformin appears to be a therapeutic candidate for fibrotic disorders. However, whether metformin could alleviate arthrofibrosis has not...

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Detalles Bibliográficos
Autores principales: Zhu, Zhenglin, Gao, Shengqiang, Zhu, Hui, Chen, Yi, Wu, Dandong, Chen, Zhiyu, Huang, Yanran, Wu, Xiangdong, Hu, Ning, Chen, Di, Huang, Wei, Chen, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338908/
https://www.ncbi.nlm.nih.gov/pubmed/37457314
http://dx.doi.org/10.1016/j.jot.2023.05.011