Pemetrexed induces ROS generation and cellular senescence by attenuating TS‐mediated thymidylate metabolism to reverse gefitinib resistance in NSCLC

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKI) are strongly recommended for non‐small‐cell lung cancer (NSCLC) patients harbouring active EGFR mutations, while drug resistance makes exploring resistance mechanisms and seeking effective therapeutic strategies urgent endeavours...

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Detalles Bibliográficos
Autores principales: Chen, Yun, Zhang, Chen, Jin, Shidai, Li, Jun, Dai, Jiali, Zhang, Zhihong, Guo, Renhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339075/
https://www.ncbi.nlm.nih.gov/pubmed/37278440
http://dx.doi.org/10.1111/jcmm.17799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339075/
https://www.ncbi.nlm.nih.gov/pubmed/37278440
http://dx.doi.org/10.1111/jcmm.17799

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