Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation

Copper is an essential component in the mitochondrial respiratory chain complex IV (cytochrome c oxidases). However, whether any nucleolar factor(s) is(are) involved in regulating the mitochondrial copper homeostasis remains unclear. The nucleolar localized Def-Capn3 protein degradation pathway clea...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Jinsong, Wang, Shuai, Zhu, Haozhe, Cui, Wei, Gao, Jianan, Gao, Ce, Yu, Bo, Liu, Bojing, Chen, Jun, Peng, Jinrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339200/
https://www.ncbi.nlm.nih.gov/pubmed/37456842
http://dx.doi.org/10.1016/j.isci.2023.107220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339200/
https://www.ncbi.nlm.nih.gov/pubmed/37456842
http://dx.doi.org/10.1016/j.isci.2023.107220

Ejemplares similares