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Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation

Copper is an essential component in the mitochondrial respiratory chain complex IV (cytochrome c oxidases). However, whether any nucleolar factor(s) is(are) involved in regulating the mitochondrial copper homeostasis remains unclear. The nucleolar localized Def-Capn3 protein degradation pathway clea...

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Detalles Bibliográficos
Autores principales: Wei, Jinsong, Wang, Shuai, Zhu, Haozhe, Cui, Wei, Gao, Jianan, Gao, Ce, Yu, Bo, Liu, Bojing, Chen, Jun, Peng, Jinrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339200/
https://www.ncbi.nlm.nih.gov/pubmed/37456842
http://dx.doi.org/10.1016/j.isci.2023.107220