Discovery of ecnoglutide – A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog

OBJECTIVE: Glucagon-like peptide (GLP)-1 is an incretin hormone that acts after food intake to stimulate insulin production, enhance satiety, and promote weight loss. Here we describe the discovery and characterization of ecnoglutide (XW003), a novel GLP-1 analog. METHODS: We engineered a series of...

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Detalles Bibliográficos
Autores principales: Guo, Wanjun, Xu, Zheng, Zou, Haixia, Li, Feng, Li, Yao, Feng, Jing, Zhu, Zhiyi, Zheng, Qing, Zhu, Rui, Wang, Bin, Li, Yan, Hao, Sujuan, Qin, Hong, Jones, Catherine L., Adegbite, Eric, Telusca, Libnir, Fenaux, Martijn, Zhong, Weidong, Junaidi, Mohammed K., Xu, Susan, Pan, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339203/
https://www.ncbi.nlm.nih.gov/pubmed/37364710
http://dx.doi.org/10.1016/j.molmet.2023.101762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339203/
https://www.ncbi.nlm.nih.gov/pubmed/37364710
http://dx.doi.org/10.1016/j.molmet.2023.101762

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