High-Throughput Chromatographic Separation of Oligonucleotides: A Proof of Concept Using Ultra-Short Columns

[Image: see text] Ion-pairing reversed-phase liquid chromatography (IP-RPLC) is the reference separation technique for characterizing oligonucleotides (ONs) and their related impurities. The aim of this study was to better understand the retention mechanism of ONs, evaluate the applicability of the...

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Detalles Bibliográficos
Autores principales: Lardeux, Honorine, Fekete, Szabolcs, Lauber, Matthew, D’Atri, Valentina, Guillarme, Davy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339280/
https://www.ncbi.nlm.nih.gov/pubmed/37384898
http://dx.doi.org/10.1021/acs.analchem.3c01934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339280/
https://www.ncbi.nlm.nih.gov/pubmed/37384898
http://dx.doi.org/10.1021/acs.analchem.3c01934

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