Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer’s disease patient lymphocytes

Introduction: Implicated in both aging and Alzheimer’s disease (AD), mammalian target of rapamycin (mTOR) is overactive in AD brain and lymphocytes. Stimulated by growth factors such as insulin, mTOR monitors cell health and nutrient needs. A small molecule oral drug candidate for AD, simufilam targ...

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Detalles Bibliográficos
Autores principales: Wang, Hoau-Yan, Pei, Zhe, Lee, Kuo-Chieh, Nikolov, Boris, Doehner, Tamara, Puente, John, Friedmann, Nadav, Burns, Lindsay H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339288/
https://www.ncbi.nlm.nih.gov/pubmed/37457922
http://dx.doi.org/10.3389/fragi.2023.1175601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339288/
https://www.ncbi.nlm.nih.gov/pubmed/37457922
http://dx.doi.org/10.3389/fragi.2023.1175601

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