A single ascending dose study of single‐stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers

RO7062931 is an N‐acetylgalactosamine (GalNAc)‐conjugated single‐stranded oligodeoxyribonucleotide complementary to hepatitis B virus RNA. GalNAc conjugation targets the liver through the asialoglycoprotein receptor (ASGPR). This phase I single ascending dose (SAD) study evaluated the safety, tolera...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheung, Tsang Tommy, Luk, Andrea On Yan, Zhang, Yuchen, Pavlovic, Vedran, Wat, Cynthia, Das, Sudip, Surujbally, Bernadette, Triyatni, Miriam, Grippo, Joseph F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339693/
https://www.ncbi.nlm.nih.gov/pubmed/37147890
http://dx.doi.org/10.1111/cts.13531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339693/
https://www.ncbi.nlm.nih.gov/pubmed/37147890
http://dx.doi.org/10.1111/cts.13531

Ejemplares similares