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A single ascending dose study of single‐stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers

RO7062931 is an N‐acetylgalactosamine (GalNAc)‐conjugated single‐stranded oligodeoxyribonucleotide complementary to hepatitis B virus RNA. GalNAc conjugation targets the liver through the asialoglycoprotein receptor (ASGPR). This phase I single ascending dose (SAD) study evaluated the safety, tolera...

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Detalles Bibliográficos
Autores principales:	Cheung, Tsang Tommy, Luk, Andrea On Yan, Zhang, Yuchen, Pavlovic, Vedran, Wat, Cynthia, Das, Sudip, Surujbally, Bernadette, Triyatni, Miriam, Grippo, Joseph F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339693/ https://www.ncbi.nlm.nih.gov/pubmed/37147890 http://dx.doi.org/10.1111/cts.13531

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