Translation of the efficacy of antibody–drug conjugates from preclinical to clinical using a semimechanistic PK/PD model: A case study with RC88

Three semimechanistic pharmacokinetic/pharmacodynamic (PK/PD) models, Simeoni, Jumbe, and Hybrid, were used for the efficacy translation of RC88 from preclinical to clinical. RC88 is a mesothelin‐targeting antibody–drug conjugate for malignant solid tumor. In the preclinical study, the relationship...

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Detalles Bibliográficos
Autores principales: Li, Qiaoning, Wang, Ling, Zhang, Jinfeng, Zhao, Guorui, Liu, Zhihao, Ma, Xinting, Jiang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339704/
https://www.ncbi.nlm.nih.gov/pubmed/37259689
http://dx.doi.org/10.1111/cts.13526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339704/
https://www.ncbi.nlm.nih.gov/pubmed/37259689
http://dx.doi.org/10.1111/cts.13526

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