Cargando…

A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo

Acute lung injury (ALI) is an inflammatory condition and there are no effective treatments. A novel new compound----colchicine-myricetin hybrid (CMyrH) was herein designed and synthesized. To evaluate the activity of CMyrH in ALI, we used a bleomycin (BLM) induced BEAS-2B injury model in vitro and e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zhiyue, Yan, Xueqin, Wei, Jiangchun, Pu, Liuyang, Zhu, Guanbao, Cao, Yongkai, Liu, Zhanyan, Liu, Yaqian, Li, Yan, Li, Limin, Li, Xinping, Wu, Zhengzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340118/ https://www.ncbi.nlm.nih.gov/pubmed/37456754 http://dx.doi.org/10.3389/fphar.2023.1224906

Ejemplares similares

Design, synthesis and biological evaluation of a novel colchicine-magnolol hybrid for inhibiting the growth of Lewis lung carcinoma in Vitro and in Vivo
por: Li, Zhiyue, et al.
Publicado: (2022)

Design, synthesis and evaluation of a myricetin and nobiletin hybrid compound for alleviating hyperuricemia based on metabolomics and gut microbiota
por: Li, Yan, et al.
Publicado: (2023)

Chaihu Shugan San ameliorated cognitive deficits through regulating gut microbiota in senescence-accelerated mouse prone 8
por: Li, Zhiyue, et al.
Publicado: (2023)

Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
por: Yang, Hui-Wen, et al.
Publicado: (2023)

Pharmacological Actions of Myricetin in the Nervous System: A Comprehensive Review of Preclinical Studies in Animals and Cell Models
por: Li, Jie, et al.
Publicado: (2021)

Myricetin activates the Caspase-3/GSDME pathway via ER stress induction of pyroptosis in lung cancer cells
por: Han, Jicheng, et al.
Publicado: (2022)

Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting M(pro) and Ameliorates Pulmonary Inflammation
por: Xiao, Ting, et al.
Publicado: (2021)

Identification of Glycine Receptor α3 as a Colchicine-Binding Protein
por: Zhou, Xikun, et al.
Publicado: (2018)

Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways
por: Yang, Wei, et al.
Publicado: (2021)

Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway
por: Chen, Tingting, et al.
Publicado: (2023)

Myricetin Attenuated Diabetes-Associated Kidney Injuries and Dysfunction via Regulating Nuclear Factor (Erythroid Derived 2)-Like 2 and Nuclear Factor-κB Signaling
por: Yang, Zi-Jun, et al.
Publicado: (2019)

Inhibition of the Glycine Receptor alpha 3 Function by Colchicine
por: Muñoz-Montesino, Carola, et al.
Publicado: (2020)

Myricetin: A Dietary Molecule with Diverse Biological Activities
por: Semwal, Deepak Kumar, et al.
Publicado: (2016)

Myricetin, the Main Flavonoid in Syzygium cumini Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5
por: Gaspar, Renato Simões, et al.
Publicado: (2020)

Antioxidant Potential and Inhibition of Mitochondrial Permeability Transition Pore by Myricetin Reduces Aluminium Phosphide-Induced Cytotoxicity and Mitochondrial Impairments
por: Salimi, Ahmad, et al.
Publicado: (2021)

Dihydromyricetin hexaacetate
por: Li, Wei, et al.
Publicado: (2010)

Myricetin: a Multifunctional Flavonol in Biomedicine
por: Agraharam, Gopikrishna, et al.
Publicado: (2022)

M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice
por: Zhou, Xiao-Ling, et al.
Publicado: (2020)

The Association Between Usage of Colchicine and Pneumonia: A Nationwide, Population-Based Cohort Study
por: Tsai, Tsung-Lin, et al.
Publicado: (2019)

Does Transient Receptor Potential Vanilloid Type 1 Alleviate or Aggravate Pathological Myocardial Hypertrophy?
por: Yan, Qiqi, et al.
Publicado: (2021)

Myricetin as a Promising Molecule for the Treatment of Post-Ischemic Brain Neurodegeneration
por: Pluta, Ryszard, et al.
Publicado: (2021)

Behavioral Phenotypes of Foxg1 Heterozygous Mice
por: Younger, Skyler, et al.
Publicado: (2022)

Compound Heterozygous CHAT Gene Mutations of a Large Deletion and a Missense Variant in a Chinese Patient With Severe Congenital Myasthenic Syndrome With Episodic Apnea
por: Liu, Zhimei, et al.
Publicado: (2019)

Effect of Myricetin on Primary Open-angle Glaucoma
por: Yang, Qing, et al.
Publicado: (2018)

Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury
por: Tang, Yuanjun, et al.
Publicado: (2021)

Amelioration of AOM/DSS-Induced Murine Colitis-Associated Cancer by Evodiamine Intervention is Primarily Associated with Gut Microbiota-Metabolism-Inflammatory Signaling Axis
por: Wang, Mengxia, et al.
Publicado: (2021)

Extracting myricetin and dihydromyricetin simultaneously from Hovenia acerba seed by Ultrasound-Assisted extraction on a lab and small Pilot-Scale
por: Zhang, Xiaonan, et al.
Publicado: (2023)

Comparative Analysis of Radical Adduct Formation (RAF) Products and Antioxidant Pathways between Myricetin-3-O-Galactoside and Myricetin Aglycone
por: Li, Xican, et al.
Publicado: (2019)

Protection against H(2)O(2)-evoked toxicity in HT22 hippocampal neuronal cells by geissoschizine methyl ether via inhibiting ERK pathway
por: Hu, Shengquan, et al.
Publicado: (2022)

Study on the mechanism of action of colchicine in the treatment of coronary artery disease based on network pharmacology and molecular docking technology
por: Yu, Yunfeng, et al.
Publicado: (2023)

The efficacy and safety of Niaoduqing granules in the treatment of diabetic kidney disease: a systematic review and meta-analysis
por: Song, Chaoqun, et al.
Publicado: (2023)

Effect of Astragaloside IV on improving cardiac function in rats with heart failure: a preclinical systematic review and meta-analysis
por: Zhang, Zhiyuan, et al.
Publicado: (2023)

Modified Qing’e Formula protects against UV-induced skin oxidative damage via the activation of Nrf2/ARE defensive pathway
por: Zhu, Shan, et al.
Publicado: (2022)

Non-coding RNAs: The recently accentuated molecules in the regulation of cell autophagy for ovarian cancer pathogenesis and therapeutic response
por: Peng, Bi, et al.
Publicado: (2023)

Small molecules targeting Pin1 as potent anticancer drugs
por: Zhang, Jing, et al.
Publicado: (2023)

Hydrophobically Modified Glucan as an Amphiphilic Carbohydrate Polymer for Micellar Delivery of Myricetin
por: Yang, Weiyu, et al.
Publicado: (2019)

Distribution and metabolism of daidzein and its benzene sulfonates in vivo (in mice) based on MALDI-TOF MSI
por: Jiao, Yanxiao, et al.
Publicado: (2022)

Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway
por: Liao, Hai-han, et al.
Publicado: (2019)

Synthesis and Biological Activity of Myricetin Derivatives Containing Pyrazole Piperazine Amide
por: Liu, Fang, et al.
Publicado: (2023)

Editorial: Discovering novel anticancer molecules and revealing the pharmacological mechanism of gastrointestinal carcinoma
por: Xia, Yong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c2hdh2dkmi84o659c2ivdvu5kd