Small Molecule RBI2 Disrupts Ribosome Biogenesis through Pre-rRNA Depletion

SIMPLE SUMMARY: Ribosome biosynthesis has emerged as an excellent target for inhibition of cancer cell growth and proliferation. We used a high throughput screen to identify potent inhibitors of ribosome synthesis in malignant melanoma cells. Here, we show that the newly identified ribosome biogenes...

Descripción completa

Detalles Bibliográficos
Autores principales: Scull, Catherine E., Twa, Guy, Zhang, Yinfeng, Yang, Naiheng J., Hunter, Robert N., Augelli-Szafran, Corinne E., Schneider, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340317/
https://www.ncbi.nlm.nih.gov/pubmed/37444413
http://dx.doi.org/10.3390/cancers15133303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340317/
https://www.ncbi.nlm.nih.gov/pubmed/37444413
http://dx.doi.org/10.3390/cancers15133303

Ejemplares similares