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Small Molecule RBI2 Disrupts Ribosome Biogenesis through Pre-rRNA Depletion
SIMPLE SUMMARY: Ribosome biosynthesis has emerged as an excellent target for inhibition of cancer cell growth and proliferation. We used a high throughput screen to identify potent inhibitors of ribosome synthesis in malignant melanoma cells. Here, we show that the newly identified ribosome biogenes...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340317/ https://www.ncbi.nlm.nih.gov/pubmed/37444413 http://dx.doi.org/10.3390/cancers15133303 |