Cell-Free DNA Extracted from CSF for the Molecular Diagnosis of Pediatric Embryonal Brain Tumors

SIMPLE SUMMARY: We demonstrate that, in pediatric embryonal brain tumors, cell-free DNA extracted from CSF can be used for whole exome sequencing (WES), with informative results in 83% of samples. Importantly, in comparison to the WES of primary tumor tissue, clonal heterogeneity is identified in mo...

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Detalles Bibliográficos
Autores principales: Chicard, Mathieu, Iddir, Yasmine, Masliah Planchon, Julien, Combaret, Valérie, Attignon, Valéry, Saint-Charles, Alexandra, Frappaz, Didier, Faure-Conter, Cécile, Beccaria, Kévin, Varlet, Pascale, Geoerger, Birgit, Baulande, Sylvain, Pierron, Gaelle, Bouchoucha, Yassine, Doz, François, Delattre, Olivier, Waterfall, Joshua J., Bourdeaut, Franck, Schleiermacher, Gudrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340330/
https://www.ncbi.nlm.nih.gov/pubmed/37444642
http://dx.doi.org/10.3390/cancers15133532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340330/
https://www.ncbi.nlm.nih.gov/pubmed/37444642
http://dx.doi.org/10.3390/cancers15133532

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