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Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice
Inflammation has been associated with depression, and innate immune receptors, such as the Toll-like receptor (TLR) 2/4 in the medial prefrontal cortex (mPFC), are crucial for chronic stress-induced depression-related behaviors in mice. HMGB1, a putative ligand for TLR2/4, has been suggested to prom...
Autores principales: | Kitaoka, Shiho, Tomohiro, Ayaka, Ukeshima, Shinya, Liu, Keyue, Wake, Hidenori, Kimura, Shinya H., Yamamoto, Yasuhiko, Nishibori, Masahiro, Furuyashiki, Tomoyuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340449/ https://www.ncbi.nlm.nih.gov/pubmed/37443823 http://dx.doi.org/10.3390/cells12131789 |
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