The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts

M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 (PfeEF2), thereby preventing protein synthesis. The parasite clearance profile after drug treatment in preclinical st...

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Detalles Bibliográficos
Autores principales: Parkyn Schneider, Molly, Looker, Oliver, Rebelo, Maria, Khoury, David S., Dixon, Matthew W. A., Oeuvray, Claude, Crabb, Brendan S., McCarthy, James, Gilson, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340534/
https://www.ncbi.nlm.nih.gov/pubmed/37457953
http://dx.doi.org/10.3389/fcimb.2023.1211613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340534/
https://www.ncbi.nlm.nih.gov/pubmed/37457953
http://dx.doi.org/10.3389/fcimb.2023.1211613

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